The ACO1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ACO1, Aconitase 1, and IRP1. This antibody recognizes Human, Mouse, and Rat antigen. The ACO1 Antibody has been validated for the following applications: Western Blot.
Description
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes